Spironolactone transgender

Does spironolactone inhibit breast growth?

If you are taking the androgen blocker called spironolactone without estrogen because you do not want visible changes, you might see some breast growth. This growth happens slowly, so you can stop taking it if you do not want breast growth. Breast growth from spironolactone is usually small and reversible.

How quickly does spironolactone lower testosterone?

Interestingly, administration of the main metabolite of spironolactone, canrenone, appears to decrease testosterone by 50–60% within hours in healthy men (13) and in conjunction with oestradiol, spironolactone decreases testosterone (14). Cyproterone acetate is a steroidal anti-androgen and works in two ways.

What hormones do transgender males take?

Medications used in hormone therapy for transgender men include androgens and anabolic steroids like testosterone (by injection and other routes) to produce masculinization, suppress estrogen and progesterone levels, and prevent/reverse feminization; GnRH agonists and antagonists to suppress estrogen and progesterone …

Does spironolactone affect mood?

Spironolactone does not typically cause depression or mood changes. If you do notice changes in mood while taking it, let your doctor know. Sometimes, spironolactone is prescribed to promote hair growth in women because it’s an antiandrogen—that means it blocks the male hormones that may lead to hair loss in women.

Can spironolactone make you gain weight?

There are concerns that spironolactone can cause weight gain, but there isn’t much evidence it does. For example, the package insert for the drug doesn’t list weight gain as a side effect. Along with weight gain, many people worry that spironolactone will make their skin look worse when they first start taking it.

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Does Spiro increase estrogen?

Spironolactone has been found in some studies to increase levels of estradiol, an estrogen, although many other studies have found no changes in estradiol levels.

What are the adverse effects of spironolactone?

Spironolactone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • vomiting.
  • diarrhea.
  • stomach pain or cramps.
  • enlarged or painful breasts in men or women.
  • irregular menstrual periods.

Is there an alternative to spironolactone?

Amiloride and triamterene may be used instead of spironolactone. They have a direct effect on the renal tubule, impairing sodium reabsorption in exchange for potassium and hydrogen.

What are the long term side effects of spironolactone?

If you take too much: If you take too much of this drug, you may have the following symptoms:

  • drowsiness.
  • confusion.
  • skin rash.
  • nausea.
  • vomiting.
  • dizziness.
  • diarrhea.
  • changes in your body’s electrolytes, which can cause irregular heart rate or muscle pain and cramping.

How long does a transgender person have to take hormones?

The extent of these changes and the time interval for maximum change varies across patients and may take up to 18 to 24 months to occur. Use of anti-androgenic therapy as an adjunct helps to achieve maximum change. Hormone therapy improves transgender patients’ quality of life (20).

Does estrogen make a man feminine?

Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis.

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What does hormones do for transgender?

Feminizing hormone therapy is used to induce physical changes in your body caused by female hormones during puberty (secondary sex characteristics) to promote the matching of your gender identity and your body (gender congruence).

What should you not take with spironolactone?

Avoid taking salt substitutes that contain potassium or potassium supplements while taking spironolactone. Try to avoid foods high in potassium (such as avocados, bananas, coconut water, spinach, and sweet potato) because eating these foods may lead to potentially fatal hyperkalemia (high blood potassium levels).

Can you lose weight on spironolactone?

There is no evidence that spironolactone works specifically for weight loss. But spironolactone might help reduce weight that’s related to fluid retention, especially in women with bloating and swelling due to PMS. If you experience weight gain due to PMS, you may want to talk to your doctor about spironolactone.

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